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Premarin (including Prempro, Premphase, Prempac, and Premelle) is a drug made doxepin up of conjugated estrogens obtained from the urine of pregnant mares -- put out in many forms (pills, creams, injections, patches, vaginal rings) and is used to reduce the symptoms of menopause in women or women who have had a hysterectomy .
Hypersensitivity, pregnancy, breastfeeding, estrogen depending malignant tumors, doxepin undiagnosed genital or uterine bleeding, thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancers) . Cautiousness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (while taking estrogens in history); family hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history (especially cholelithiasis), severe liver failure, jaundice (including one during pregnancy doxepin in history), hepatic porphyria, leiomyoma, hypercalcemia associated with bone metastases caused by breast cancer, underactive thyroid, porphyria, endometriosis, asthma .